Flexibility of Motor Pattern Generation Across Stimulation Conditions by the Neonatal Rat Spinal Cord
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چکیده
منابع مشابه
Flexibility of motor pattern generation across stimulation conditions by the neonatal rat spinal cord.
Previous studies have demonstrated that "locomotor-like" rhythmic patterns can be evoked in the isolated neonatal rat spinal cord by several means, including pharmacological neuromodulation and electrical stimulation of various pathways. Recent studies have used stimulation of afferent pathways to evoke rhythmic patterns, relying on synaptic activation of interneuronal systems rather than globa...
متن کاملFlexibility of motor pattern generation across stimulation conditions
8 David A. Klein, Angelica Patino, and Matthew C. Tresch 9 Northwestern University 10 Departments of Biomedical Engineering, Physical Medicine and Rehabilitation, and Physiology 11 12 Running title: Flexibility of CPGs 13 14 Address for correspondence: 15 Matthew Tresch 16 Northwestern University 17 Feinberg School of Medicine 18 Ward 5-198, Physiology 19 303 E. Chicago Ave 20 Chicago, IL 60611...
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The rhythmogenic capacity of the tail-innervating segments (L4-Co3) of the spinal cord was studied in isolated spinal cord and tail-spinal cord preparations of neonatal rats. Bath-applied serotonin/N-methyl-D-aspartate (NMDA) failed to produce a robust sacrococcygeal rhythmicity following midlumbar transection of the spinal cord. By contrast, a regular alternating left-right rhythm could be ind...
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Spinal cords from 2- to 8-day-old rats, maintained in vitro, were used to investigate the effects of discrete electrical stimuli applied to the ventrolateral funiculus (VLF) on motor neuron activity recorded from the lumbar ventral roots. Short trains of stimuli (1-3 s) delivered to one VLF in the low cervical region elicited rhythmic activity that persisted for up to 30 s. Responses consisted ...
متن کاملSpinal Cord Stimulation in the Pithed Rat
The role of endogenous calcitonin gene-related peptide (CGRP) in the nonadrenergic noncholinergic depressor response to spinal cord stimulation was studied in the pithed rat in vivo. Pithed rats were given hexamethonium (2 mg/kg per minute i.v.) to block autonomic outflow, and mean blood pressure was artificially maintained at approximately 100 mm Hg with methoxamine (10-15 ,ug/kg per minute i....
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ژورنال
عنوان ژورنال: Journal of Neurophysiology
سال: 2010
ISSN: 0022-3077,1522-1598
DOI: 10.1152/jn.00961.2009